Ocean Biomedical, Inc. (NASDAQ: OCEA) Announces Award of New Patent to Scientific Co-Founder Dr. Jake Kurtis for Novel Malaria Vaccine Target
Breakthrough approach targets stage in malaria lifecycle responsible for all clinical disease and death, has potentially significantly greater efficacy compared with vaccines targeting other stages
Patent will add third potential parasite target PfCDPK-5 to Ocean Biomedical’s malaria vaccine program, building on prior groundbreaking research on PfGARP and PfSEA
Each target has potential to induce protection by controlling a unique part of the malaria cycle and may be developed individually or in a combined formulation for maximum effectiveness
In recent studies published and reviewed in Nature,
Ocean’s breakthrough approach targets the blood-stage portion of the malaria lifecycle – the stage responsible for all clinical disease and death – therefore has the potential of significantly greater efficacy compared with vaccines targeting other stages. If combined with the new target PfCDPK-5 and PfSEA, the vaccine has the potential to shut down the parasite at multiple points in its cycle. In coming months,
Addressing a Global Unmet Need
In addition to this multi-pronged vaccine program,
Malaria is the greatest single-agent killer of children on the planet, killing approximately 627,000 individuals in 2022. Artemisinin-based drug therapy remains the mainstay of treatment, but the spread of parasites resistant to this family of compounds threatens recent progress achieved by antimalarial campaigns and underscores the urgent need to identify new anti-malarial drugs.
Data has demonstrated that the family of small molecule drugs in development by Dr. Kurtis’ team are highly specific for PfGARP binding, are non-toxic in multiple in vitro and in vivo systems, have excellent pharmacokinetic properties, and rapidly clear parasitemia in animal models.
“Our current vaccine formulation has an impressive ability to induce parasite cell death and we are hopeful that this latest addition might even increase that effectiveness,” commented Dr.
“The progress we have been able to make thus far in advancing novel targets is a testament to Ocean Biomedical’s innovative model and deep partnership with premier research institutions. We are hopeful that Dr. Kurtis’ discoveries will lead to a powerful vaccine that can save hundreds of thousands of lives, and we are proud to help advance this important work,” said
“Falciparum malaria is a leading cause of death in children world-wide and our global malaria treatment strategy relies almost exclusively on artemisinin-based drugs. The recent emergence of high grade resistance to artemisinin is an existential threat to this strategy and mandates the development of novel classes of antimalarials. We are thrilled to announce our discovery of a novel class of antimalarials which have to potential to save hundreds of thousands of lives,” said Dr. Chirinjeev Kathuria, co-founder and Executive Chairman.
“This discovery, coupled with the powerful approach in our malaria vaccine program, will lead to long term shareholder value growth and appreciation,” commented
About Ocean Biomedical
To learn more, visit www.oceanbiomedical.com
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The announced discoveries were based solely on laboratory and animal studies. Ocean Biomedical has not conducted any studies that show similar efficacy or safety in humans. There can be no assurances that this treatment will prove safe or effective in humans, and that any clinical benefits of this treatment is subject to clinical trials and ultimate approval of its use in patients by the FDA. Such approval, if granted, could be years away.
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