Ocean Biomedical (NASDAQ: OCEA) Extends Patent Rights for Breakthrough Idiopathic Pulmonary Fibrosis Discovery To Europe
Patent notice extends global coverage for breakthrough discovery, with potential for treating Idiopathic Pulmonary Fibrosis (IPF) and other fibrotic diseases, including Scleroderma, Nonalcoholic Steatohepatitis (NASH), Hermansky-Pudlak syndrome (HPS), and Alcoholic Liver Disease.
Providence, RI, June 23, 2023 (GLOBE NEWSWIRE) -- Ocean Biomedical, Inc. (NASDAQ: OCEA) announced today that Scientific Co-founder Dr. Jack A. Elias, MD received notice from the European Patent Office of its intention to grant European patent rights for Methods and Compositions relating to the treatment of fibrosis using Ocean’s anti-Chitinase 1 small molecule candidate (“Small Molecule X”), a new target discovered by Dr. Elias that appears to be a major factor in controlling—and inhibiting—fibrosis progression.
Ocean’s approach has shown an 85%–90% reduction in collagen accumulation in four “gold standard” IPF and HPS pulmonary fibrosis animal models. This treatment approach is anticipated to be well-tolerated based on data from original (non-Ocean) clinical studies and recent EPA data.
Fibrosis is a condition of “runaway scarring” that affects most organs and tissues, and is a leading cause of morbidity and mortality. In the United States, over 100,000 people are suffering from Idiopathic Pulmonary Fibrosis (IPF), with a similar patient population in Europe. There are currently only two approved drugs for treating IPF, both with limited impact, merely slowing the decline of lung function, and significant side effects. IPF is a disease with a major unmet need for curative therapeutics.
Ocean Biomedical’s unique treatment discovery uses a previously-trialed, well-tolerated small molecule to inhibit the mechanisms of fibrosis generally. As the patent notes, this approach has potential application in multiple fibrotic conditions in addition to IPF, including: scleroderma; collagen vascular disease; lupus; rheumatoid arthritis; genetic pulmonary fibrosis; Hermansky-Pudlak syndrome; radiation pneumonitis; asthma; asthma with airway remodeling; chemotherapy-induced pulmonary fibrosis; radiation fibrosis; Gaucher’s disease; interstitial lung disease; retroperitoneal fibrosis; myelofibrosis; interstitial or pulmonary vascular disease; fibrosis or interstitial lung disease associated with drug exposure; interstitial lung disease associated with exposures such as asbestosis, silicosis, and grain exposure; chronic hypersensitivity pneumonitis; an intestinal or abdominal adhesion; an intestinal or abdominal adhesion; cardiac fibrosis; kidney fibrosis; cirrhosis; nonalcoholic steatohepatitis (NASH); and nonalcoholic steatohepatitis (NASH) with liver fibrosis.
“I’ve been working with patients with pulmonary fibrosis conditions throughout my career and I’ve always been disappointed in the treatment options available,” commented Dr. Elias, former Chair of Yale’s Department of Internal Medicine. “I’m hopeful we can develop these discoveries into a new, more effective treatment approach for patients and doctors.”
“Ocean Biomedical is committed to advancing new discoveries to meet large unmet medical needs globally, and we will continue to push our anti-fibrosis program forward to advance this important work,” said Elizabeth Ng, Chief Executive Officer of Ocean Biomedical.
“Combining innovative science with a great management team has potential for great impact,” said Dr. Chirinjeev Kathuria, Ocean Biomedical’s co-founder and Executive Chairman. “We are pleased to receive this patent extension and look forward to getting new drugs to patients in Europe and the world.”
About Ocean Biomedical
Ocean Biomedical, Inc. is a Providence, Rhode Island-based biopharma company with an innovative business model that accelerates the development and commercialization of scientifically compelling assets from research universities and medical centers. Ocean Biomedical deploys the funding and expertise to move new therapeutic candidates efficiently from the laboratory to the clinic, to the world. Ocean Biomedical is currently developing five promising discoveries that have the potential to achieve life-changing outcomes in lung cancer, brain cancer, pulmonary fibrosis, and the prevention and treatment of malaria. The Ocean Biomedical team is working on solving some of the world’s toughest problems, for the people who need it most.
To learn more, visit www.oceanbiomedical.com.
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Any discoveries announced by the Company are based solely on laboratory and animal studies. The Company has not conducted any studies that show similar efficacy or safety in humans. There can be no assurances that this treatment will prove safe or effective in humans, and that any clinical benefits of this treatment is subject to clinical trials and ultimate approval of its use in patients by the FDA. Such approval, if granted, could be years away.
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Source: Ocean Biomedical, Inc.